Processing Actionable Data in Genomics

Experience bioinformatics approaches to processing genomic data and distilling consequential biomedical information. Genomic sequencing technologies deliver massive volumes of data that require dedicated handling methods and diverse abilities for troubleshooting. This hands-on course focuses on UNIX-based analysis tasks commonly employed in the field. Instruction covers general considerations ranging from experiment configuration, data QC, and software systems, to tuning of algorithms and visualization of results. In addition, assigned work with public datasets will provide students with weekly hands-on experience with several widely used techniques, including read mapping, variant calling, annotation, and pipeline construction. Class sessions consist of video lectures covering slides, some assigned reading, quizzes, and directed forum participation. Mandatory data processing homework is a significant part of this class.

By the end of the course, you will be able to:

• Compare the utility of different types of sequencing experiments
• Structure bioinformatic pipelines to fit the experiment
• Implement steps in bioinformatic processing
• Critique genomic processing results

For more information on this course, please contact: appliedscience@ucsd.edu