About the ADMET in Drug Development Program
All courses in this certificate are now available ONLINE.
The ADMET processes – Absorption, Distribution, Metabolism, Excretion, and Toxicology – form one of the foundations of all modern drug discovery and development. It has been reported that 50% of drug failures in development and clinical trials are due to poor ADMET properties. In order to minimize these costly failures, the paradigm of drug discovery and development has therefore been shifting to examining and optimizing these properties as early as possible. This requires virtually every organization that embarks on the challenge of creating pharmaceutical solutions to health or agricultural concerns to become expert at analyzing these processes. Accordingly, successful professionals in the field must be aware of and proficient in the examination of each of these processes, and employers must ensure the continued development of a workforce capable of understanding and facilitating systems and environments where these processes can be researched and evaluated with integrity and efficiency.
Despite the core importance of the ADMET processes to pharmaceutical science, few scientific, regulatory or business professionals possess a complete understanding of the elements of ADMET. Traditional science education prepares research specialists in one or two processes, but not the full complement and cycle. To the extent that scientific professionals understand and can incorporate ADMET concepts into their research and development projects, they are increasingly able to provide successful solutions to the R&D challenge, and they become more valuable to their organizations.
Individual courses in each of these processes offered by Extension over the past few years have confirmed the interest of the profession in strengthening understanding and application of each process element.
Program Benefits
The specialized certificate program in ADMET Processes offers several benefits to scientific professionals seeking to enhance their knowledge and expertise in this field. Here are some key advantages of this course:
- Comprehensive understanding of ADMET processes, including Absorption, Distribution, Metabolism, Excretion, and Toxicology.
- Early insights into practical strategies for assessing and enhancing ADMET ultimately lead to minimizing costly setbacks and improving the chances of successful drug development.
- The practical approach emphasizes the skills and tools necessary to address the challenges encountered in R&D endeavors and find successful solutions.
- A valuable addition to professional credentials, demonstrating a commitment to staying updated with the latest drug discovery and development advancement.
- Opportunities to network with like-minded individuals can lead to collaborations, knowledge sharing, and exchange of ideas.
Key Program Topics
- Study design concepts for the determination of pharmacokinetic parameters
- Predict human pharmacokinetics using animal pharmacokinetics and in vitro data.
- Strengths and risks associated with a molecule based on its pharmacokinetic profile
- Enzymes and mechanisms of drug metabolism
- Use in vitro assays to predict drug-drug interactions
- Principles of toxicology in drug discovery and clinical testing
- The role of drug metabolites in drug discovery
ADMET in Drug Development
Required Courses
All 3 courses are required.
Electives
Complete at least 2.0 units.
Conditions for Admission
The primary audience for the program is practicing professionals with a science degree, currently working in the pharmaceutical field. Professionals with legal, business or clinical backgrounds, or science professionals considering entering the pharmaceutical field, may also be attracted to the program.
Complete the application and pay application fee.
Advisory Board
Demiana Faltaos, PhD
Avijit Ghosh, PhD
Joseph Ma, PhD., PharmD.
Curt Thompson, PhD, MBA
Related Programs
Drug Discovery and Development
Quality Assurance and Control
