Structural Biology in Drug Discovery

Get an overview of the application of structural biology in the discovery of new therapeutics. This course is for research scientists who want to improve their knowledge of the drug discovery process and will explore the fundamentals of macromolecular structure biology with an emphasis on how those principles can be applied to the discovery of therapeutic agents. The course starts with a survey of macromolecular structure and a detailed analysis of certain protein classes that have been found to be important for drug purposes. We will describe how structural information can be used to optimize therapeutic proteins such as antibodies. The course will discuss how computational techniques can be used to identify small molecule ligands by applying docking techniques