Pathogenic Mechanisms and Therapeutic Perspectives in Alcohol-Associated Liver Disease

Featured Speaker: Professor Cristina Llorente

Factors impacting the intestinal microbiome are
associated with a vast array of diseases. Among
them, gastric-acid suppression contributes to the
progression of alcohol-associated liver disease.
Notably, the presence of intestinal cytolytic E.
faecalis in alcoholic hepatitis holds significant clinical
importance — as a novel predictor of mortality.
Targeted bacteriophages against cytolytic E. faecalis
present a therapeutic alternative in mitigating
ethanol-induced liver injury in preclinical work.
Additionally, the pivotal role of small intestinal
goblet cells in preserving intestinal homeostasis
offers therapeutic alternatives to prevent bacterial
translocation and the development of alcoholassociated
liver disease.

Presenter Biography

Cristina Llorente is Assistant Professor
at UC San Diego with a primary focus on
deciphering the molecular mechanisms involved
in the progression of liver diseases. Her research is
translational and centered on the study of hostmicrobe
interactions and liver disease. Llorente
received her Ph.D. from Autonomous University of
Madrid in Spain.

Coordinator: Yanina Odin